search for




 

Risk of falls in community-dwelling older adults aged 65 or over with type 2 diabetes mellitus: a systematic review
Physical Therapy Rehabilitation Science 2018;7:139-45
Published online September 30, 2018
© 2018 Korean Academy of Physical Therapy Rehabilitation Science.

Sujin Hwang

Department of Physical Therapy, Division of Health Science, Baekseok University, Cheonan, Republic of Korea
Correspondence to: Sujin Hwang (ORCID https://orcid.org/0000-0001-8471-0103) Department of Physical Therapy, Division of Health Science, Baekseok University, 76 Munam-ro, Dongnam-gu, Cheonan 31065, Republic of Korea, Tel: 82-41-550-2309, Fax: 82-41-550-2829, E-mail: sujin928@gmail.com
Received August 25, 2018; Revised September 17, 2018; Accepted September 17, 2018.
cc This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Objective

Older persons with diabetes mellitus (DM) are particularly more likely to have fallen in the previous year than those without DM. The purpose of this study was to investigate the relationship between the risk of falls and type 2 DM in older adults who are 65 years of age or above.

Design

A systematic review.

Methods

PubMed and other two databases were searched up to August 2, 2018. Observational and cohort studies evaluating fall risk in people who are 65 years of age or above with DM were included. This review extracted the following information from each study selected: first author’s surname, year of publication, country, average follow-up period, sex, age at enrollment, study population, measurement variables, relative risk, 95% confidence intervals and controlled variables.

Results

This review involved nine cohort studies with 3,765 older adults with DM and 12,989 older adults without DM. Six studies compared with or without DM and two studies compared fallers with non-fallers with DM. Risk factors for falls included impaired cognitive function, diabetes-related complications (peripheral nerve dysfunction, visual impairment), and physical function (balance, gait velocity, muscle strength, and severity of physical activities).

Conclusions

People who are 65 years of age or above with DM have increased risk of falling caused by impaired cognitive function, peripheral nerve dysfunction, visual impairment, and physical function in community-dwellers. For adults who are 65 years of age or older with DM, research fields and clinical settings should consider therapeutic approaches to improve these risk factors for falls.

Keywords : Accidental falls, Community, Diabetes mellitus
Introduction

According to the World Health Organization, the number of people with diabetes mellitus (DM) has risen from 108 million in 1980 to 422 million in 2014 worldwide, and in 2015, an estimation of 1.6 million deaths were directly caused by DM [1]. Diabetes is a major cause of blindness, kidney failure, lower limb amputation as well as heart attacks and stroke [2]. These diseases are directly threatening to human life, therefore, management of DM is a very important consideration in public health. Appropriately 20% of older adults aged 65 to 75 years and about 40% of adults aged 80 years or over [3,4]. Although DM is a very common disease among elderly persons, most studies on DM investigating the clinical problems, complications and secondary impairments have been conducted regardless of age, and there is a relatively lack of focusing the problems in older adults 65 years or over with DM.

Falling is another problem that is common in the older population 65 years or over [5]. Approximately one in three community-dwelling older adults aged 65 or over suffer from one or more falls each year [5]. The incidence of falls appears more often in older persons with DM, and therefore several prospective studies reported DM to bes a risk factor of falls and fall-related injuries [6-10]. Falls in older persons with DM may lead to disabilities based on having decreased motivation and limitations in activities, resulting in ultimately lower quality of life even if it is not complicated with fractures. Previous studies reported that an increased risk of falling in diabetic patients is related with previous falls, poor lower extremity function, poor balance, a history of coronary heart disease, arthritis, being overweight, musculoskeletal pain, depression, poor vision, peripheral neuropathy, polypharmacy including hypnotics, peripheral neuropathy, and insulin therapy [7,10,11]. They may correlate to the presence of diabetic complications, long duration of disease, sex, or age difference or the study design. This study conducted a comprehensive systematic review of prospective observational studies to investigate whether DM was an independent risk factor for falls in community-dwelling individuals aged 65 or over.

Methods

This systematic review was performed on Patient/ Participants/Population/Problem, Intervention, Comparison, Outcome with Timing, Setting Study Design. The search strategy of this review was performed by one researcher and one librarian.

Search strategy

This review was conducted in accordance with the checklist of the Meta-analysis of Observational Studies in Epidemiology (MOOSE). This study conducted literature review using three academic electronic databases (PubMed, EMbase, and CINAHL) for cohort studies published up to August 3, 2018. The following MeSH terms, words and combinations of words were used in constructing the systematic search: (diabetes mellitus OR diabetic OR DM) AND (falls OR falling OR accidental falls) AND (old OR older OR elder OR elder*) AND (observational OR cohort). The search was restricted to studies in humans and those written English. The details of the search with five electronic databases are listed in Table 1 [7-11,12-15]. In addition, the reference lists of all identified relevant publications were reviewed.

Study selection

After completing the search in the databases, the researcher searched by hand to remove duplicate studies used on reference lists of obtained studies. The review questions and inclusion criteria were based on the MOOSE guidelines. Studies were included if (1) the participants were aged 65 and over; (2) the participants had a diagnosis of type 2 DM and were using anti-diabetic agents; (3) prospective cohort studies that investigated the association between diabetes and the risk of falls; (4) studies provided at least age-adjusted risk estimates of falls comparing diabetic to non-diabetic individuals. Studies were excluded if: the article was written in languages other than English; the article was not published as the full reports, such as case reports, commentaries, conference abstracts and letters to editors; the study had a retrospective design; the participants had a diagnosis of type 1 DM, gestational diabetes in addition to type 2 DM; the participants were 64 years of age or less. Studies were excluded if they did not provide data that allowed calculation of standard errors for effect estimates and if the estimates had not been adjusted for age. This review included observational and cohort studies for the assessment of the relationship between fall risk and DM. Two searchers discussed about the search process and selection of studies to include all available studies. This review included nine cohort studies included in a qualitative synthesis. The title and/or abstracts of the studies retrieved using the search strategy was screened independently by the review author to identify studies that potentially met the inclusion and exclusion criteria outlined above. The full text of these potentially eligible studies was retrieved and independently assessed for eligibility by the reviewer.

Data extraction

For each study selected, this review extracted data information of the first author’s surname, year of publication, country, average follow-up period, sex, age at enrollment, study population, outcome, measurement, relative risk, 95% confidence interval, and controlled variables for by matching or multivariable analysis. This review also extracted information for assessment of the risk of bias including selection of participants, confounding variables, measurement of intervention (exposure), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), and selective reporting (reporting bias). This review used the RoBANS to assess internal validity of selected studies [16].

Results

Literature search and characteristics of the included studies

Based on the initial search strategies, this review retrieved a total of 359 studies from three mainstream electronic databases and the contents of 24 out of the 359 studies were relevant to the current review. Fifteen out of the 24 articles were further excluded with the following reasons: participants were not 65 years of age or over and/or it was a mixed population study, participants were not community-dwellers, the study was not an observational and/or cohort study and retrospective cohort; 9 articles were cohort studies (Table 1). This review involved nine cohort studies with 3,765 older adults with DM and 12,989 older adults without DM. Six studies compared with or without DM [8-10,12-15] and two studies compared fallers to non-fallers in those with DM [11,15]. One of nine cohort studies compared younger people (65 to 74 years old) to older people (75 years or over) with DM (Table 1).

Risk factors of falling in 65 years of age or over community-dwelling persons with DM

Risks of falls included impaired cognitive function, diabetes-related complications (peripheral nerve dysfunction, visual impairment), and impaired physical function (balance, gait velocity, muscle strength, and severity of physical activities). Seven studies reported visual impairment as a risk of falling in 65 years of age or over community-dwellers with DM [8-11,14,15]. They measured visual impairment, such as corrected visual acuity, contrast sensitivity, and depth perception (near and distant). Five studies reported impaired cognitive function as a risk of falling, and they measured cognitive function with the mini-mental state examination, modified mini-mental state examination, recall, orientation, executive function, trails B, and digit symbol score [7,8,10,13,14]. Peripheral nerve dysfunction was reported as another important risk factor of falling in five studies [8,9,11,13,15]. They measured peripheral nerve dysfunction using an ordinal scale, loss of light touch discrimination, peroneal nerve conduction velocity, peroneal nerve compound muscle action potential amplitude, vibration perception, and loss of pressure sensitivity.

Impaired physical function including balance, muscle strength, gait velocity, and previous fall experience was also reported to be a risk of falling. Four studies measured balance function with out measures, such as tandem walk score, tandem stance performance, standing balance time, balance test scale, and chair stand test [8,9,13,14]. Muscle strength was assessed for knee extension and grip strength in four studies [8-10,13], and gait velocity was assessed in four studies [7,8,13,14]. Previous experience of falls was reported in four studies [7,10,13,14], and the severity of impaired physical activity was reported in six studies that measured activities of daily living, physical activity time per day, physical activity at least once a week (percentage), independent mobility, and the amount of time spent on their feet every day (hours) [7,8,10,11,13,15]. Three of nine studies assessed hypertension as a risk of falls [9,13,14], and two of nine studies measured glycemic control (HBA1C [%]) [9,15].

Publication bias in all included studies

All included studies showed low risk in measurement of intervention (exposure), blinding of outcome measurement and incomplete outcome data. However, one of nine studies showed high risk in confounding variables, and another one of nine studies showed high risk in selective outcome reporting.

Discussion

This review aimed to identify risk factors of falling in community-dwelling older adults 65 years of age or over with DM. As results of all included studies, the most common risk factors of falling were impaired physical function, cognitive impairment and diabetes-related complications. Physical impairments that were identified included severity of impaired physical activities, muscle strength, balance and walking velocity, and diabetes-related complications including peripheral nerve dysfunction and visual impairment. Gravesande and Richardson reviewed the non-pharmacological risk factors for falling in older adults who were 50 years of age or over, with type 2 DM [17]. They reported that the most common risk factors were impaired balance, reduced walking velocity, peripheral neuropathy, and comorbid conditions, such as osteoarthritis and heart disease [17]. Chiba et al. [18] investigated risk factors of falls in persons 60 years of age or over with type 2 DM and they reported that the risk factors were hypoglycemia, cognitive impairment, a high fall risk index score, and a high Timed Up-and-Go test score. They also reported that cognitive impairment, hypoglycemia, and fall risk indices show statistically significant differences between those with and without multiple falls. Maurer et al. [19] determined whether diabetes is an independent risk factor for falls in elderly residents of a long-term care facility with type 2 DM, and they reported peripheral neuropathy, hypoglycemia, visual impairments, and hypertension as the most important risk factors of falling in type 2 DM. This review investigated the population with DM who were 65 years of age or over, but showed similar risk factors of falling with those who were younger with DM.

This review showed several DM-related risk factors, such as peripheral dysfunction, poor visual acuity, poor depth perception, cognitive impairment, poor postural balance and walking velocity, reduced physical activities, and muscle strength, were associated with falling in adults with DM who were 65 years of age or over. The results of this review showed that the risk factors of falling were similar to those of the younger age group than this review. This review did not consider demographic information, such as race and family support, and did not consider the time after the onset of disease and diabetes severity, such as HbA1C. This review investigated cohort and observational studies, but not randomized controlled trials. Future studies should consider the review of randomized controlled trials, and examine the effect of therapeutic approaches on risk factors of falling in community-dwelling older adults who are 65 years of age or over with DM.

Acknowledgments

This research was supported by basic science research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018050771).

Conflict of Interest

The authors declared no potential conflicts of interest with respect to the authorship and/or publication of this article.

Figures
Fig. 1. Flow diagram of this review.
Fig. 2. Risk of bias presented as percentages across all included studies.
Tables

Table 1

Characteristics of cohort studies of the association between diabetes mellitus and risk of falls

First author, yearCountryFollow-up periodPopulation (% female)Age (y) at enrollmentStudy populationResult
SubgroupRelativerisk95% confidence intervalControlled variables
Blackwood, 2018 [7]United States1,17165 yearsThe 2010 wave of the Health and Retirement Study65-74 yearsㆍCommon characteristic
65-74 years, 662 Executive function1.061.01-1.11ㆍComorbidities
75 or over years, 509 Delayed recallㆍFunctional status
Older groupㆍMedications
 Executive function1.071.01-1.13ㆍPsychosocial
 Delayed recall1.281.03-1.59functioning
Schwartz et al., 2002 [8]United States7.2±1.9 years9,249 (100)The Study of Osteoporotic Fractures, a prospective cohort studyBalance1.34/2.981.00-1.81/1.67-5.32ㆍCommon characteristic
No-DM, 8,620CHD1.43/3.701.06-1.92/2.08-6.57ㆍComorbidities
No insulin, 530Arthritis1.45/3.921.08-1.95/2.21-6.95ㆍFunctional status
Insulin, 99Peripheral neuropathy1.49/3.831.11-1.99/2.16-6.79ㆍMedications
Patel et al., 2008 [11]United Kingdom15065 yearsThe Merton and Sutton Community Diabetes registerVibration threshold19.0±7.76.7-50.2ㆍCommon characteristic
Fallers, 61ㆍMedical examination
Nonfallers, 89
Pijpers et al., 2012 [10]The Netherlands1,14565 yearsLASA, a cohort studyPain score1.541.01-2.34ㆍCommon characteristic
No-DM, 1,060Self-PH1.551.05-2.31ㆍComorbidities
DM, 85Physical activity1.591.05-2.41ㆍFunctional status
Grip strength1.581.05-2.40ㆍMedications
MMSE1.591.05-2.42ㆍPsychosocial
functioning
Schwartz et al., 2008 [9]United States4.9 years3,075 (44.6)73.6±2.7Health ABC study, a prospective cohort studyA1C 6%4.361.32-14.46ㆍCommon characteristic
No-DM, 262970-79CMAP1.501.07-1.12ㆍComorbidities
DM, 446Vision1.410.97-2.04ㆍFunctional status
Renal function1.381.11-1.71ㆍMedications
DBP1.541.21-1.95
Tilling et al., 2006 [15]United77 (58)65 yearsFemale2.3361.144-4.766ㆍCommon characteristic
KingdomFalls, 30Age>751.621.014-2.586ㆍComorbidities
No falls, 47Frame to mobilize2.6791.998-3.593ㆍFunctional status
Stick to mobilize1.8391.048-3.227ㆍMedications
A1C>7%7.832.948-20.799
Stroke1.9291.143-3.257
van Hateren et al., 2012 [12]The Netherlands563 (52.9)70 yearsObservational studySymptomatic OH2.871.09-7.55ㆍCommon characteristic
No-DM, 211Age1.071.01-1.14ㆍComorbidities
DM 352
Volpato et al., 2005 [13]Norway3 years878 (100)65 yearsWHAS, an epidemiological studyRF1.381.04-1.81ㆍCommon characteristic
No-DM, 742RRF1.691.18-2.43ㆍComorbidities
No insulin, 97ㆍFunctional status
Insulin, 39ㆍMedications
Yau et al., 2013 [14]United States10.1 years3,075 (44.6) No-DM, 2,356 No insulin, 602 Insulin, 11773.6±2.770-79Health ABC study, a prospective cohort studySex (female)1.851.08-3.17ㆍCommon characteristics
Race2.101.24-3.56ㆍFunctional status
Study site2.341.35-4.06ㆍMedications
Fell number2.231.33-3.73
SBS2.731.57-4.75
Insulin use (yes)1.240.64-2.41
A1C level1.761.02-3.05

DM: diabetes mellitus, CHD: coronary heart disease, LASA: the longitudinal aging study Amsterdam, PH: physical health, MMSE: mini-mental state examination, Health ABC study: the health aging and body composition study, CMAP: compound muscle action potential, DBP: diastolic blood pressure, WHAS: the women’s health and aging study, RF: risk of falls, RRF: recurrent risk of falls, SBS: standing balance score.


References
  1. , (1994). Prevention of diabetes mellitus. Geneva: World Health Organization, pp. 108
  2. Galesanu, C, Buzduga, C, Florescu, A, Moisii, L, and Ciubotaru, V (2015). Diabetes mellitus, chronic complication in patients with acromegaly: case report and review of the literature. Rev Med Chir Soc Med Nat Iasi. 119, 92-6.
    Pubmed
  3. Kamel, HK, Rodriguez-Saldaña, J, Flaherty, JH, and Miller, DK (1999). Diabetes mellitus among ethnic seniors: contrasts with diabetes in whites. Clin Geriatr Med. 15, 265-78.
    Pubmed CrossRef
  4. Morley, JE (1999). An overview of diabetes mellitus in older persons. Clin Geriatr Med. 15, 211-24.
    Pubmed CrossRef
  5. Shumway-Cook, A, and Woollacott, MH (2010). Motor control : translating research into clinical practice. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins
  6. Kachroo, S, Kawabata, H, Colilla, S, Shi, L, Zhao, Y, and Mukherjee, J (2015). Association between hypoglycemia and fall-related events in type 2 diabetes mellitus: analysis of a U.S. commercial database. J Manag Care Spec Pharm. 21, 243-53.
    Pubmed
  7. Blackwood, J (2018). Cognitive function and falls in older adults with type 2 diabetes mellitus. J Geriatr Phys Ther.
    Pubmed CrossRef
  8. Schwartz, AV, Hillier, TA, Sellmeyer, DE, Resnick, HE, Gregg, E, and Ensrud, KE (2002). Older women with diabetes have a higher risk of falls: a prospective study. Diabetes Care. 25, 1749-54.
    Pubmed CrossRef
  9. Schwartz, AV, Vittinghoff, E, Sellmeyer, DE, Feingold, KR, de Rekeneire, N, and Strotmeyer, ES (2008). Diabetes-related complications, glycemic control, and falls in older adults. Diabetes Care. 31, 391-6.
    KoreaMed CrossRef
  10. Pijpers, E, Ferreira, I, de Jongh, RT, Deeg, DJ, Lips, P, and Stehouwer, CD (2012). Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors: the Longitudinal Ageing Study Amsterdam. Age Ageing. 41, 358-65.
    CrossRef
  11. Patel, S, Hyer, S, Tweed, K, Kerry, S, Allan, K, and Rodin, A (2008). Risk factors for fractures and falls in older women with type 2 diabetes mellitus. Calcif Tissue Int. 82, 87-91.
    Pubmed CrossRef
  12. van Hateren, KJ, Kleefstra, N, Blanker, MH, Ubink-Veltmaat, LJ, Groenier, KH, and Houweling, ST (2012). Orthostatic hypotension, diabetes, and falling in older patients: a cross-sectional study. Br J Gen Pract. 62, e696-702.
    Pubmed KoreaMed CrossRef
  13. Volpato, S, Leveille, SG, Blaum, C, Fried, LP, and Guralnik, JM (2005). Risk factors for falls in older disabled women with diabetes: the women's health and aging study. J Gerontol A Biol Sci Med Sci. 60, 1539-45.
    CrossRef
  14. Yau, RK, Strotmeyer, ES, Resnick, HE, Sellmeyer, DE, Feingold, KR, and Cauley, JA (2013). Diabetes and risk of hospitalized fall injury among older adults. Diabetes Care. 36, 3985-91.
    Pubmed KoreaMed CrossRef
  15. Tilling, LM, Darawil, K, and Britton, M (2006). Falls as a complication of diabetes mellitus in older people. J Diabetes Complications. 20, 158-62.
    Pubmed CrossRef
  16. Seo, HJ, Kim, SY, Lee, YJ, Jang, BH, Park, JE, and Sheen, SS (2016). A newly developed tool for classifying study designs in systematic reviews of interventions and exposures showed substantial reliability and validity. J Clin Epidemiol. 70, 200-5.
    CrossRef
  17. Gravesande, J, and Richardson, J (2017). Identifying non-pharmacological risk factors for falling in older adults with type 2 diabetes mellitus: a systematic review. Disabil Rehabil. 39, 1459-65.
    CrossRef
  18. Chiba, Y, Kimbara, Y, Kodera, R, Tsuboi, Y, Sato, K, and Tamura, Y (2015). Risk factors associated with falls in elderly patients with type 2 diabetes. J Diabetes Complications. 29, 898-902.
    Pubmed CrossRef
  19. Maurer, MS, Burcham, J, and Cheng, H (2005). Diabetes mellitus is associated with an increased risk of falls in elderly residents of a long-term care facility. J Gerontol A Biol Sci Med Sci. 60, 1157-62.
    Pubmed CrossRef

 

Full Text(PDF) Free

Cited By Articles
  • CrossRef (0)

Funding Information
  • Authorship and ethical issues